Butyrolactone I

Cell permeable, potent and selective cyclin-dependent kinase CDK-1 (CDC2), -2 and -5 inhibitor [1-4, 9, 10].
Apoptosis inducer [6, 7, 9].
Antitumor agent [5, 9].
Inhibits cell cycle progression at the G1/S and G2/M transitions [8].
Shown to prevent the phosphorylation of retinoblastoma protein and H1 histone [2, 10].
Important probe for understanding the cellular roles of CDKs [4].
Inhibitor of α-glucosidases [12].
Maturation inhibitor of sheep oocytes [11].
Product References