1 1

Adipogen

Ixazomib [MLN2238]

Ixazomib [MLN2238]

SKU: AG-CR1-3670-M001
Brand: Adipogen
Lead Time: 2-3 weeks
  • Potent selective and reversible proteasome inhibitor (all proteolytic subunits).
  • Targets the chymotrypsin-like β5 subunit of the constitutive 20S proteasome (IC50=3.4nM). Cross-reacts and inhibits the trypsin-like β2 subunit (IC50=3.5μM) and the caspase-like/peptidyl-glutamyl peptide-hydrolyzing (PGPH) β1 subunit (IC50=0.03μM).
  • Anticancer compound effective in cell-based assays, in xenografts and against multiple myeloma in vivo.
  • In vitro, induces cell cycle arrest and apoptosis in human cancer cell lines including multiple myeloma.
  • Biologically active form of the prodrug MLN9708 (Prod. No. AG-CR1-3671).
  • Exhibits improved pharmacodynamics and antitumor activity compared to bortezomib (Prod. No. AG-CR1-3602) in various B cell lymphoma models, due to a greater tumor to blood ratio of proteasome inhibition that ultimately translates into improved tumor pharmacodynamic response and antitumor activity in several tumor xenograft models.
$431.00 SGD
$431.00 SGD
Sale Sold out
Pack Size

General Specifications

1. Formula: C14H19BCl2N2O4
2. MW: 361.0
3. CAS: 1072833-77-2
4. Purity Chemicals: ≥98% (HPLC)
5. Appearance: White solid.
6. Solubility: Soluble in DMSO (20mg/ml), ethanol (10mg/ml) or DMF (20mg/ml). Poorly soluble in aqueous buffers.
7. Identity: Determined by 1H-NMR.
8. Shipping: AMBIENT
9. Short Term Storage: +4°C
10. Long Term Storage: -20°C

Safety & Documentation

MSDS
Data Sheet

View full details

Disclaimer: Products are chemical reagents for research use
only and are not intended for human use. We do not sell to patients.