Adipogen
Z-VAD-FMK (Cell permeable)
Z-VAD-FMK (Cell permeable)
Cell permeable, non-selective broad-spectrum caspase inhibitor [1, 3, 7, 8]. Binds irreversibly to the catalytic site of caspase proteases [1].
The peptide is O-methylated in the P1 position on aspartic acid, providing enhanced stability and increased cell permeability [1].
Inhibits ICE-family protease/caspase processing, leading to apoptosis and autophagy induction [2-4, 6, 9].
Decreases proteasome activity [5].
Potent inhibitor of caspase-1 activation in NLRP3/NALP3-induced cells [10].
Used in apoptosis and inflammasome studies.
Couldn't load pickup availability
General Specifications
1. Formula: C22H30FN3O72. MW: 467.5
3. Sequence: Z-Val-Ala-DL-Asp(OMe)-fluoromethylketone
4. CAS: 187389-52-2
5. Purity Chemicals: ≥95% (HPLC)
6. Appearance: White solid.
7. Solubility: Soluble in DMSO, acetonitrile or dimethyl formamide.
8. Shipping: AMBIENT
9. Short Term Storage: +4°C
10. Long Term Storage: -20°C
Safety & Documentation
Error in entry: MSDS, https://cdn.shopify.com/s/files/1/0716/2553/9802/files/MSDS_AG_CP3_0002.pdf?v=1734335188, Manual Z-VAD-FMK (Cell permeable), https://cdn.shopify.com/s/files/1/0716/2553/9802/files/Manual_AG-CP3-0002-Z-VAD-FMK-Cell-permeable.pdf?v=1734398694
{# This line will help debug any improperly formatted entries #}
Disclaimer: Products are chemical reagents for research use
only and are not intended for human use. We do not sell to patients.