Heptelidic acid

Antibiotic [1, 2].
Potent selective glyceraldehyde 3-phosphate dehydrogenase (GAPDH) inhibitor. Binds to the essential Cys149 residue in the catalytic site of GAPDH [3-7, 10, 11].
Anticancer compound [8]. Selectively kills high-glycolytic cancer cells through glucose-dependent active ATP deprivation [12].
Antimalarial [9].
Apoptosis inhibitor. DNA fragmentation and caspase-3 activation inhibitor [13,16].
Selective and competitive inhibitor of mammalian DNA polymerases beta, lambda and terminal deoxynucleotidyl transferase (TdT) in family X of pols [14].
Reduces lactate secretion and causes reductions in overall protein synthesis and production of IFN-α and TNF.