Adipogen
Cyclosporin A
Cyclosporin A
SKU: AG-CN2-0079-M100
Brand: Adipogen
Lead Time: 2-3 weeks
- Potent immunosuppressant (same as FK-506 (Prod. No. AG-CN2-0047) and rapamycin (Prod. No. AG-CN2-0025)).
- Forms a complex with cyclophilin. Inhibits the activity of the calcium/calmodulin-dependent protein phosphatase 2B (PP2B; calcineurin). Prevents the dephosphorylation of nuclear factor of activated T cells (NFAT) transcription factor, leading to disruption of T cell activation.
- Suppresses proliferation of cytotoxic T cells and inhibits the production of T cell-derived mediators such as interleukin-2 (IL-2).
- Prevents rejection of transplanted organs.
- Anti-inflammatory compound in the treatment of several inflammatory skin diseases (e.g. atopic dermatitis) and with potential anti-rheumatic activity (rheumatoid arthritis).
- Antibacterial. Antifungal. Antiparasitic.
- Apoptosis inhibitor. Inhibits the mitochondrial permeability transition pore (MPTP) from opening, thus inhibiting cytochrome c release.
- NF-κB suppressor by induction of unfolded protein response (UPR).
- Anti-cancer compound. Apoptosis and autophagy inducer.
- Inhibits nitric oxide synthesis induced by interleukin-1α, lipopolysaccharides and TNF-α.
- Potently induces highly cardiogenic progenitors from embryonic stem (ES) cells.
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$446.00 SGD
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General Specifications
1. Formula: C62H111N11O122. MW: 1202.6
3. Merck Index: 14: 2752
4. CAS: 59865-13-3
5. RTECS: GZ4120000
6. Source/Host Chemicals: Isolated from Tolypocladium inflatum.
7. Purity Chemicals: ≥98%
8. Appearance: White solid.
9. Solubility: Soluble in DMSO, ethanol, methanol, dichlormethane, chloroform or acetone. Insoluble in water.
10. Shipping: AMBIENT
11. Short Term Storage: +4°C
12. Long Term Storage: -20°C
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Disclaimer: Products are chemical reagents for research use
only and are not intended for human use. We do not sell to patients.