Cyclosporin A

Potent immunosuppressant (same as FK-506 (Prod. No. AG-CN2-0047) and rapamycin (Prod. No. AG-CN2-0025)).
Forms a complex with cyclophilin. Inhibits the activity of the calcium/calmodulin-dependent protein phosphatase 2B (PP2B; calcineurin). Prevents the dephosphorylation of nuclear factor of activated T cells (NFAT) transcription factor, leading to disruption of T cell activation.
Suppresses proliferation of cytotoxic T cells and inhibits the production of T cell-derived mediators such as interleukin-2 (IL-2).
Prevents rejection of transplanted organs.
Anti-inflammatory compound in the treatment of several inflammatory skin diseases (e.g. atopic dermatitis) and with potential anti-rheumatic activity (rheumatoid arthritis).
Antibacterial. Antifungal. Antiparasitic.
Apoptosis inhibitor. Inhibits the mitochondrial permeability transition pore (MPTP) from opening, thus inhibiting cytochrome c release.
NF-κB suppressor by induction of unfolded protein response (UPR).
Anti-cancer compound. Apoptosis and autophagy inducer.
Inhibits nitric oxide synthesis induced by interleukin-1α, lipopolysaccharides and TNF-α.
Potently induces highly cardiogenic progenitors from embryonic stem (ES) cells.