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Adipogen

Phorbol 12-myristate 13-acetate [PMA]

Phorbol 12-myristate 13-acetate [PMA]

SKU: AG-CN2-0010-M001
Brand: Adipogen
Lead Time: 2-3 weeks

PMA/TPA is the most commonly-used phorbol ester.
Binds to and activates protein kinase C (PKC) at nM concentrations.
Induces cell growth arrest through a variety of pathways including the mitogen-activated protein kinases (MAPKs), p38 and c-Jun N-terminal kinase (JNK) pathways mediated by cyclin dependent kinase (CDK) inhibitors such as p21WAF1/CIP1, p27KIP1, p15 and p16.
Potent mouse skin tumor promoter.
Promoter of inducible NOS (iNOS; NOS II).
Apoptosis inducer.
Potential effective cancer therapeutic agent.
Inhibitor of anti-lipolytic activity of insulin.
PMA treatment stimulates THP-1 cells and generates M0 macrophages (M0).

$428.00 SGD
$428.00 SGD
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Pack Size

General Specifications

1. Formula: C36H56O8
2. MW: 616.8
3. Merck Index: 14: 7332
4. CAS: 16561-29-8
5. RTECS: QH4377000
6. Source/Host Chemicals: Semisynthetic.
7. Purity Chemicals: ≥98% (HPLC)
8. Appearance: White to off-white powder.
9. Solubility: Soluble in DMSO (20mg/ml), 100% ethanol (20mg/ml), methanol, acetone, ether or dimethylformamide; almost insoluble in aqueous buffers.
10. Identity: Determined by 1H-NMR
11. Shipping: AMBIENT
12. Short Term Storage: +4°C
13. Long Term Storage: -20°C

Safety & Documentation

Error in entry: MSDS, https://cdn.shopify.com/s/files/1/0716/2553/9802/files/MSDS_AG_CN2_0010.pdf?v=1734335188, Manual Phorbol 12-myristate 13-acetate [PMA], https://cdn.shopify.com/s/files/1/0716/2553/9802/files/Manual_AG-CN2-0010-Phorbol-12-myristate-13-acetate-PMA.pdf?v=1734398694

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Disclaimer: Products are chemical reagents for research use
only and are not intended for human use. We do not sell to patients.