Adipogen
Phorbol 12-myristate 13-acetate [PMA]
Phorbol 12-myristate 13-acetate [PMA]
PMA/TPA is the most commonly-used phorbol ester.
Binds to and activates protein kinase C (PKC) at nM concentrations.
Induces cell growth arrest through a variety of pathways including the mitogen-activated protein kinases (MAPKs), p38 and c-Jun N-terminal kinase (JNK) pathways mediated by cyclin dependent kinase (CDK) inhibitors such as p21WAF1/CIP1, p27KIP1, p15 and p16.
Potent mouse skin tumor promoter.
Promoter of inducible NOS (iNOS; NOS II).
Apoptosis inducer.
Potential effective cancer therapeutic agent.
Inhibitor of anti-lipolytic activity of insulin.
PMA treatment stimulates THP-1 cells and generates M0 macrophages (M0).
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General Specifications
1. Formula: C36H56O82. MW: 616.8
3. Merck Index: 14: 7332
4. CAS: 16561-29-8
5. RTECS: QH4377000
6. Source/Host Chemicals: Semisynthetic.
7. Purity Chemicals: ?98% (HPLC)
8. Appearance: White to off-white powder.
9. Solubility: Soluble in DMSO (20mg/ml), 100% ethanol (20mg/ml), methanol, acetone, ether or dimethylformamide; almost insoluble in aqueous buffers.
10. Identity: Determined by 1H-NMR
11. Shipping: AMBIENT
12. Short Term Storage: +4°C
13. Long Term Storage: -20°C
Safety & Documentation
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only and are not intended for human use. We do not sell to patients.