IL-37 (human) ELISA Kit

IL-37 (IL-1F7; IL-1H4) is an IL-1 family member that is expressed only in certain types of human organs and cells such as heart, thymus, testis, kidney, mononuclear cells (PBMCs) and dendritic cells. IL-37 is an inhibitor of innate immunity with anti-inflammatory properties. It binds to the interleukin-18 receptor (IL-18R) and its co-receptor SIGIRR. IL-37 is secreted as a full-length and as a processed form starting from amino acid Val46. It plays an important role as a link between innate and adaptive immunity and acts as an inhibitor of autoimmune diseases and tumor growth. IL-37 also inhibited Lipopolysaccharide (LPS)-induced immunological reaction and LPS-induced osteoclast formation and bone resorption. New insights indicate that IL-37 protein forms a head-to-head homodimer and this structure limits its bioactivity. Variants with mutations converting the cytokine into a monomeric form are 13-fold more active than the dimeric IL-37. Circulating concentrations of IL-37 have been shown to be lower in older compared with younger adults, despite chronic low-grade elevations in pro-inflammatory cytokines in older adults. A recent study provides evidence that IL-37 concentrations decline in older age and are related to selective markers of healthspan in healthy humans and suggests a possible role of IL-37 in biological aging in humans.