Adipogen
DLL4 (human):Fc (human) (rec.) (highly active mutant)
DLL4 (human):Fc (human) (rec.) (highly active mutant)
The Notch ligand delta-like protein 4 (DLL4) is expressed highly and selectively within the arterial endothelium and has been shown to function as a ligand for Notch1 and Notch4. It is induced by VEGF as a negative feedback regulator and acts to prevent overexuberant angiogenic sprouting, promoting the timely formation of a well differentiated vascular network. DLL4-Notch1 signaling regulates the formation of appropriate numbers of tip cells to control vessel sprouting and branching in the mouse retina.
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General Specifications
1. Source/Host: HEK 293 cells2. Sequence: Extracellular domain of human DLL4 (aa 27-529 plus mutations) are fused at the C-terminus to the Fc portion of human IgG1.
3. Specificity: Interacts with human and mouse Notch1 with >20 fold increase in affinity relative to WT DLL4 (as confirmed by ELISA).
4. MW: ~100kDa (SDS-PAGE)
5. Purity: ≥95% (SDS-PAGE)
6. Endotoxin Content: <0.01EU/μg purified protein (LAL test).
7. Concentration: After reconstitution:
for 10µg size: 0.1mg/ml
for 100µg size: 1 mg/ml
8. Reconstitution: Reconstitute with 100µl sterile endotoxin-free water.
9. Formulation: Lyophilized. Contains PBS.
10. Shipping: BLUE ICE
11. Short Term Storage: +4°C
12. Long Term Storage: -20°C
Safety & Documentation
Error in entry: MSDS, https://cdn.shopify.com/s/files/1/0716/2553/9802/files/MSDS_AG_40B_0176.pdf?v=1734335188, Manual DLL4 (human):Fc (human) (rec.) (highly active mutant), https://cdn.shopify.com/s/files/1/0716/2553/9802/files/Manual_AG-40B-0176-DLL4-human-Fc-human-rec-highly-active-mutant.pdf?v=1734398694
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Disclaimer: Products are chemical reagents for research use
only and are not intended for human use. We do not sell to patients.