Adipogen
IL-38 (aa 3-152) (mouse) (rec.) (FLAG)
IL-38 (aa 3-152) (mouse) (rec.) (FLAG)
IL-38 (IL-1F10) mRNA is expressed in heart, placenta, fetal liver, spleen, thymus and tonsil. The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-1F10 in the inflammatory response. It has been reported that removal of the N-terminus domain of the interleukins of the IL-1F family such as IL-1F5 / 6 / 8 or 9 (also called IL-36Ra, IL-36?, IL-36? or IL-36?) is important to increase their biological activity. Recently it has been shown that IL-38 is N-terminally processed and secreted by apoptotic cells. Released processed IL-38 (20-152) binds to the receptor Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1; TIGIRR-2) at the surface of macrophages. Processed IL-38-activated IL1RAPL1 reduces the production of IL-6 leading to inflammation attenuation.
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General Specifications
1. Source/Host: E. coli2. Sequence: Mouse IL-38 [IL-1F10] (aa 3-152) is fused at the C-terminus to a FLAG®-tag.
3. MW: ~20kDa
4. Purity: ≥95% (SDS-PAGE)
5. Endotoxin Content: <0.01EU/?g purified protein (LAL test; Lonza).
6. Concentration: 0.1mg/ml after reconstitution.
7. Reconstitution: Reconstitute with 100?l sterile water.
8. Formulation: Lyophilized. Contains PBS + 0.5% Trehalose + 0.02% CHAPS
9. Shipping: BLUE ICE
10. Short Term Storage: +4°C
11. Long Term Storage: -20°C
Safety & Documentation
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only and are not intended for human use. We do not sell to patients.