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    Adipogen

    APRIL (human) (H98) (multimeric) (rec.)

    APRIL (human) (H98) (multimeric) (rec.)

    SKU: AG-40B-0088-C010
    Brand: Adipogen
    Lead Time: 2-3 weeks

    APRIL is a cytokine that belongs to the TNF superfamily and binds to TACI and BCMA. It is implicated in the regulation of tumor cell growth, is involved in monocyte/macrophage-mediated immunological processes and functions as an important survival factor for plasmablasts and bone marrow plasma cells.
    MultimericAPRIL™ is a high activity construct in which two trimeric APRIL ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively stimulates proliferation B cell. A basic amino acid sequence (QKQKKQ) close to the N-terminus of APRIL is required for binding to negatively charged sulfated glycosaminoglycan side chains of proteoglycans. Proteoglycans mediate binding of APRIL to tumor cells as well as primary lymphoid cells.

    $1,016.00 SGD
    $1,016.00 SGD
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    General Specifications

    1. Source/Host: CHO cells
    2. Sequence: The extracellular domain of human APRIL (aa 98-233) is fused at the N-terminus to human ACRP30headless (aa 16-108) and a FLAG®-tag.
    3. Specificity: Binds to human and mouse BCMA and TACI. Does not bind to proteoglycans.
    4. Biological Activity: Stimulates B cell proliferation.
    5. MW: ~32kDa (SDS-PAGE)
    6. Purity: ≥95% (SDS-PAGE)
    7. Endotoxin Content: <0.01EU/μg purified protein (LAL test; Lonza).
    8. Concentration: 10µg vial: 0.1mg/ml after reconstitution.
    100µg vial: 1mg/ml after reconstitution.
    9. Reconstitution: Reconstitute with 100μl sterile water.
    10. Formulation: Lyophilized. Contains PBS + 0.5% Trehalose.
    11. Shipping: BLUE ICE
    12. Short Term Storage: +4°C
    13. Long Term Storage: -20°C

    Safety & Documentation

    Error in entry: MSDS, https://cdn.shopify.com/s/files/1/0716/2553/9802/files/MSDS_AG_40B_0088.pdf?v=1734335188, Manual APRIL (human) (H98) (multimeric) (rec.) MultiPack, https://cdn.shopify.com/s/files/1/0716/2553/9802/files/Manual_AG-40B-0088-APRIL-human-H98-multimeric-rec.pdf?v=1734398694

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    Disclaimer: Products are chemical reagents for research use
    only and are not intended for human use. We do not sell to patients.