Adipogen
CD40L (human) (multimeric) (rec.)
CD40L (human) (multimeric) (rec.)
MultimericCD40L™ is a high activity construct in which two trimeric CD40 ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively simulates the natural membrane-assisted aggregation of CD40L in vivo. It provides a simple and equally potent alternative to [CD40L+enhancer] combinations. MultimericCD40L™ has shown to suppress alum-induced IL-1β release and caspase-1 activation in a dose-, CD40- and time dependent manner, without affecting BMDM viability. It also effectively suppressed the inflammasome function triggered by NLRP3 activators. The secretion of caspase-1 independent inflammatory mediators has been shown to be unaltered or even enhanced.
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General Specifications
1. Source/Host: CHO cells2. Sequence: Human CD40L (aa 116-261) is fused at the N-terminus to mouse ACRP30headless (aa 18-111) and a FLAG®-tag.
3. Specificity: Binds to human CD40.
4. Biological Activity: Induces B cell activation and B cell expansion (concentrations depend on the protocol, but we recommend to start at 50-100 ng/ml).
5. MW: ~35-40kDa (SDS-PAGE)
6. Purity: ≥95% (SDS-PAGE)
7. Endotoxin Content: <0.01EU/μg purified protein (LAL test, Lonza).
8. Concentration: 0.1mg/ml after reconstitution.
9. Reconstitution: Reconstitute with 100μl sterile water.
10. Formulation: Lyophilized. Contains PBS
11. Shipping: BLUE ICE
12. Short Term Storage: +4°C
13. Long Term Storage: -20°C
Safety & Documentation
Error in entry: MSDS, https://cdn.shopify.com/s/files/1/0716/2553/9802/files/MSDS_AG_40B_0010.pdf?v=1734335188, Manual CD40L (human) (multimeric) (rec.) MultiPack, https://cdn.shopify.com/s/files/1/0716/2553/9802/files/Manual_AG-40B-0010-CD40L-human-multimeric-rec.pdf?v=1734398695
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Disclaimer: Products are chemical reagents for research use
only and are not intended for human use. We do not sell to patients.