BAFF, Soluble (human) ELISA Kit (hypersensitive)

BAFF (B cell-activating factor; BLyS; B lymphocyte stimulator; TNFSF13B; TALL-1; CD257), belonging to the TNF family, is a master regulator of peripheral B cell survival, and together with IL-6, promotes Ig class-switching and plasma cell differentiation. BAFF co-stimulates activated T cells. Increased levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases, such as Sjögren’s syndrome, rheumatoid arthritis, multiple sclerosis and systemic lupus erythematosus (SLE). Furthermore, BAFF is found in inflammatory sites in which there is lymphoid neogenesis. BAFF levels are elevated in patients with multiple myeloma and B cell chronic lymphoid leukemia (B-CCL).

Product References:
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6.Increased BAFF and APRIL levels in the cerebrospinal fluid of patients with anti-neutrophil cytoplasmic antibody-related hypertrophic pachymeningitis: Y. Shimojima, et al.; Cytokine 99, 305 (2017)
7.Inhibition of membrane-bound BAFF by the anti-BAFF antibody belimumab: C. Kowalczyk-Quintas, et al.; Front. Immunol. 9, 2698 (2018)
8.B-cell profile, B-cell activating factor concentration and IgG levels in human cutaneous and mucosal leishmaniasis: C. Parodi, et al.; Parasite Immunol. e12759 (2020)
9.Evolutionarily Selected Overexpression of the Cytokine BAFF Enhances Mucosal Immune Response Against P. falciparum: V. Lodde, et al.; Front. Immunol. 11, 575103 (2020)
10.BAFF 60-mer, and differential BAFF 60-mer dissociating activities in human serum, cord blood and cerebrospinal fluid: M. Eslamy, et al.; Front. Cell Dev. Biol. 8, 577662 (2020)
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12.Kinetics of free and ligand-bound atacicept in human serum: M. Eslami, et al.; Front. Immunol. 13, 1035556 (2022)