Adipogen
20S Proteasome (human) (untagged)
20S Proteasome (human) (untagged)
The ubiquitin-proteasome pathway is the major proteolytic system in eukaryotic cells, where it catalyzes the selective degradation of short-lived regulatory proteins or the rapid turnover of misfolded proteins. One of the most important proteases in this pathway is the 26S proteasome, an ATP-dependent proteolytic complex, which is formed by the association of the barrel-shaped 20S proteasome (700kDa) and two 19S (700kDa) regulatory complexes. The 20S catalytic core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 α-subunits and 2 rings are composed of 7 β-subunits. The 20S catalytic core is able to degrade a variety of peptide substrates and poly-ubiquitinated proteins involved with apoptosis, DNA repair, endocytosis and cell cycle control.
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General Specifications
1. Source/Host: Human Erythrocytes2. Sequence: Human 20S Proteasome.
3. MW: ~700kDa
4. Purity: ≥95% (SDS-PAGE)
5. Concentration: Lot dependent.
6. Formulation: Liquid. In 50mM HEPES pH 7.6, 100mM sodium chloride, 1mM DTT.
7. Declaration: Manufactured by South Bay Bio.
8. Shipping: DRY ICE
9. Short Term Storage: -80°C
10. Long Term Storage: -80°C
Safety & Documentation
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Disclaimer: Products are chemical reagents for research use
only and are not intended for human use. We do not sell to patients.