MCE
Laduviglusib
Laduviglusib
SKU: HY-10182
Brand: MedChemExpress
Lead Time: 1-2 Weeks
Laduviglusib (CHIR-99021) is a potent, selective and orally active GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. Laduviglusib shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib enhances mouse and human embryonic stem cells self-renewal. Laduviglusib induces autophagy.
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General Specifications
1) Purity: 99.76%2) Molecular Weight: 465.34
3) Formula: C22H18Cl2N8
4) CAS No.: 252917-06-9
5) Appearance: Solid
6) Color: Off-white to light brown
7) SMILE: N#CC1=CC=C(N=C1)NCCNC2=NC=C(C(C3=CC=C(Cl)C=C3Cl)=N2)C4=NC=C(N4)C
8) Shipping: Room temperature in continental US; may vary elsewhere.
9) Storage: Powder: -20°C, 3 years ; 4°C, 2 years ; In solvent: -80°C, 1 year ; -20°C, 6 months
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Disclaimer: Products are chemical reagents for research use
only and are not intended for human use. We do not sell to patients.