MCE
Tazemetostat
Tazemetostat
SKU: HY-13803
Brand: MedChemExpress
Lead Time: 1-2 Weeks
Tazemetostat (EPZ-6438) is a potent, selective and orally available EZH2 inhibitor. Tazemetostat inhibits the activity of human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 with a Ki value of 2.5 nM. Tazemetostat inhibits EZH2 with IC50s of 11 and 16 nM in peptide assay and nucleosome assay, respectively. Tazemetostat inhibits rat EZH2 with an IC50 of 4 nM. Tazemetostat also inhibits EZH1 with an IC50 of 392 nM. Tazemetostat induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells.
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General Specifications
1) Purity: 99.93%2) Molecular Weight: 572.74
3) Formula: C34H44N4O4
4) CAS No.: 1403254-99-8
5) Appearance: Solid
6) Color: White to light yellow
7) SMILE: O=C(C1=CC(C2=CC=C(CN3CCOCC3)C=C2)=CC(N(CC)C4CCOCC4)=C1C)NCC5=C(C)C=C(C)NC5=O
8) Shipping: Room temperature in continental US; may vary elsewhere.
9) Storage: Powder: -20°C, 3 years ; 4°C, 2 years ; In solvent: -80°C, 1 year ; -20°C, 6 months
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Disclaimer: Products are chemical reagents for research use
only and are not intended for human use. We do not sell to patients.