MCE
BAY 11-7082
BAY 11-7082
BAY 11-7082 is an IκBα phosphorylation and NF-κB inhibitor. BAY 11-7082 selectively and irreversibly inhibits the TNF-α-induced phosphorylation of IκB-α, and decreases NF-κB and expression of adhesion molecules. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 (IC50=0.19, 0.96 μM, respectively). BAY 11-7082 inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells.
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General Specifications
1) Purity: 99.98%2) Molecular Weight: 207.25
3) Formula: C10H9NO2S
4) CAS No.: 19542-67-7
5) Appearance: Solid
6) Color: White to off-white
7) SMILE: N#C/C=C/S(=O)(C1=CC=C(C)C=C1)=O
8) Shipping: Room temperature in continental US; may vary elsewhere.
9) Storage: Powder: -20°C, 3 years ; 4°C, 2 years ; In solvent: -80°C, 6 months ; -20°C, 1 month
Safety & Documentation
Error in entry: 1) Datasheet, https://cdn.shopify.com/s/files/1/0716/2553/9802/files/Datasheet_HY-13453.pdf?v=1734506157 , 2) MSDS, https://cdn.shopify.com/s/files/1/0716/2553/9802/files/MSDS_HY-13453.pdf?v=1734506829 , 3) Handling Instruction, https://cdn.shopify.com/s/files/1/0716/2553/9802/files/Handling_Instructions_HY-13453.pdf?v=1734506811
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Disclaimer: Products are chemical reagents for research use
only and are not intended for human use. We do not sell to patients.