MCE
DAPT
DAPT
DAPT (GSI-IX) is a potent and orally active γ-secretase inhibitor with IC50s of 115 nM and 200 nM for total amyloid-β (Aβ) and Aβ42, respectively. DAPT inhibits the activation of Notch 1 signaling and induces cell differentiation. DAPT also induces autophagy and apoptosis. DAPT has neuroprotection activity and has the potential for autoimmune and lymphoproliferative diseases, degenerative disease and cancers treatment.
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General Specifications
1) Purity: 99.97%2) Molecular Weight: 432.46
3) Formula: C23H26F2N2O4
4) CAS No.: 208255-80-5
5) Appearance: Solid
6) Color: White to off-white
7) SMILE: FC1=CC(F)=CC(CC(N[C@H](C(N[C@H](C(OC(C)(C)C)=O)C2=CC=CC=C2)=O)C)=O)=C1
8) Shipping: Room temperature in continental US; may vary elsewhere.
9) Storage: Powder: -20°C, 3 years ; 4°C, 2 years ; In solvent: -80°C, 2 years ; -20°C, 1 year
Safety & Documentation
Error in entry: 1) Datasheet, https://cdn.shopify.com/s/files/1/0716/2553/9802/files/Datasheet_HY-13027.pdf?v=1734506156 , 2) MSDS, https://cdn.shopify.com/s/files/1/0716/2553/9802/files/MSDS_HY-13027.pdf?v=1734506829 , 3) Handling Instruction, https://cdn.shopify.com/s/files/1/0716/2553/9802/files/Handling_Instructions_HY-13027.pdf?v=1734506811
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Disclaimer: Products are chemical reagents for research use
only and are not intended for human use. We do not sell to patients.