MCE
BDNF Protein, Human
BDNF Protein, Human
Brain Derived Neurotrophic Factor (BDNF) is a neurotrophin that belongs to NGF-beta family. BDNF can bind to its high affinity receptor TrkB and activates signal transduction cascades (IRS1/2, PI3K, Akt). BDNF can also bind to the p75NTR, but the affinity for the p75NTR receptor is lower than for TrkB. BDNF is a neurotransmitter modulator, and is vital in maturation, survival and differentiation of neuronal populations during development. BDNF also participates in neuronal plasticity, which is essential for learning and memory. BDNF is widely expressed in the CNS. BDNF Protein, Human is a recombinant human BDNF (H129-R247) without tag, which is produced in E.coli.
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General Specifications
1) Purity: Greater than 95% as determined by reducing SDS-PAGE.2) Molecular Weight: Approximately 13 kDa
3) Formulation: Lyophilized after extensive dialysis against 20 mM PB, 250 mM NaCl, pH 7.2 or 4 mM HCL, pH 0.8.
4) Species: Human
5) Appearance: Lyophilized powder
6) Source: E. coli
7) Tag: Tag Free
8) Shipping: Room temperature in continental US; may vary elsewhere.
9) Storage: Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Safety & Documentation
Error in entry: 1) Datasheet, https://cdn.shopify.com/s/files/1/0716/2553/9802/files/Datasheet_HY-P7116A.pdf?v=1734506157 , 2) MSDS, https://cdn.shopify.com/s/files/1/0716/2553/9802/files/MSDS_HY-P7116A.pdf?v=1734506830 , 3) Handling Instruction, https://cdn.shopify.com/s/files/1/0716/2553/9802/files/Handling_Instructions_HY-P7116A.pdf?v=1734506805
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Disclaimer: Products are chemical reagents for research use
only and are not intended for human use. We do not sell to patients.